- 540 with the income of Ravenna by eastRoman troops ends the first phase of the Gotenkrieges. King Witigis comes into imperial shank, Italy is subordinate again to Roman rule.
- 540 renewed outbreak of fighting between the Sassanidenreich under Chosrau I. and the eastRoman realm under Justinian I. The large king conquers several cities in Roman Syria, under it also Antiochia. The war persists to 561/562 .
- 541 beginning of the second phase of the Gotenkrieges.
- 541 the Justiniani plague, how the first large Pestpandemie is called, breaksout. It should afflict from then on for over two centuries always again the Mediterranean area, to it over approx.for approximately six hundred years (until 1347 ) disappeared to 760.