Aldosteron (English.: Aldosterone) is a Steroidhormon, which is formed from Cholesterin and to the Mineralocorticoiden heard. Aldosteron is called occasionally also thirst hormone, since it is increased paid with lack of liquid.
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from Cholesterin over the intermediate stage Pregnolon the Progesteron one forms. From Hydroxylierung first Desoxycorticosteron results, by a further Hydroxylierung to Corticosteron is formed. In one develops oneself for following oxidation from itthe Aldosteron.
Aldosteron becomes in the Zona glomerulosa - which outermost layer of the suprarenal body crust - produces. Its education becomes lively over the rail of the Renin Angiotensin Aldosteron system. It increased produced:
- blood pressure drop
- of renaler lack blood circulation
function and regularization
Aldosteron adjuststhe back absorption of sodium - and chloride ions in the kidney. Parallel for this potassium -, hydrogen - and ammonium ions are separated. The main effect of the Aldosterons exists thus in an exchange of potassium and hydrogen ions against sodium ions in the distal Tubulus of the kidney.
Its effectivenesscan be restrained by Aldosteron antagonists such as Spironolacton and Canrenoat.
The effectiveness of Aldosteron on the mineral household is about 1000 time more highly than from Cortisol, because the Cortisol is converted in the aldosteronsensitiven cells by the 11-ss-Hydroxysteroiddehydrogenase type 2 to Cortison and the receptornot to activate can. The receptor affinity is alike.
An important role of the Aldosteron and the Renin Angiotensin Aldosteron system is the blood pressure regularization. Besides Aldosteron seems in the accomplishment of life-threatening stress situations necessarilyto be.
Fludrocortison is an artificial Mineralocorticoid, which can adjust a Aldosteronmangel as medicine. Side effects with high dosage: Hypokaliämie, metabolic Alkalose, water retention (edemas), blood pressure increase.
the normal value in the plasma is about 2-15 µg/100 ml. The Aldosteronspiegel is degradedwith suprarenal body crust insufficiency and shock, the Aldosteronspiegel is increased activity (Hyperaldosteronismus) with stress, after operations, with more increased Angiotensin II -.
the primary Hyperaldosteronismus ( a Conn syndrome) is rare, a secondary Hyperaldosteronismus is however more frequently with heart insufficiency and living ore erring trousers.
A lack of Aldosteron can for example in the context of an autoimmune illness (disease Addison) or with a Tuberkulose of the suprarenal bodies arise.
- ADH -- Suprarenal body -- Aldosteronantagonist -- Spironolacton -- Renin -- Angiotensin -- ACE Hemmer -- On the left of
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