Cortison

structural formula

general
name	11-Dehydro-17-hydroxycorticosteron
sum formula	C₂₁ H₂₈ O₅
other names	Cortison, Compound E, Kortison
short description	Glucocorticoid
CAS number	53-06-5
melting point	222 °C
water solubility	280 mg/l with 25 °C
steam pressure	5.80^-13 mm Hg with 25 °C
mol mass	360.45 g/mol

the name Cortison (of Latin cortex „crust “) one gave to the first active substance found in the suprarenal body crust of humans. Cortison is the inactivated form of the Glucocorticoids Cortisol. It binds neither the Glucocorticoid receptor nor the Mineralcorticoid receptor and can by the enzyme β-Hydroxy-Steroid-Dehydrogenase from Cortisol in an educated manner or into this convertedbecome. Colloquially medicines with Cortisolwirkung are called frequently „Cortison “.

1 historical
2 physiological effect
3 diseases, with those Cortison effectively is
4 side effects
- 4,1 continuous use of Cortison
- 4,2 short term ones, high-dose application
5 Web on the left of

[work on]

historical

Cortison became in the years 1936 - 1940 isolated from several working groups and differently designate: as „compound F “ of Wintersteiner, as „substance company “ by Reichstein and as „compound E “ of the working group around Kendall. The later Cortisol or Hydrocortison was manufactured 1937/ 38 of Reichstein. Later turned out,that Cortison is a preliminary stage of the actual hormone Cortisol (Hydrocortison). Synthetic Cortison variants are and. A. the Prednison, Prednisolon, Methylprednisolon, Betamethason, Dexamethason, Triamcinolon, Paramethason and Fludrocortison. Prednison and Prednisolon can be converted in the body into one another and are effect. Their effect corresponds for instance to the fivefold one the Cortisonwirkung.