Diclofenac

Diclofenac is a nichtsteroidales Analgesic (NSAR), with easy to middle Pain and Inflammations one uses. It works by a not-selective inhibition that Cyclooxygenasen (COX).

Pharmacology

Diclophenac possesses antipyretische, analgetische, anti-inflammatory and anti-rheumatism tables Effectiveness. Responsible for this effectiveness an inhibition of the Cyclooxygenasen and thus an inhibition of the synthesis are inflammatory Prostaglandine. Possibly Diclofenac is direct to LipoxygenaseMetabolism takes part and suppresses the education of Leukotrienen.

Side effects

Typical side effects are stomach and intestine complaints, by an inhibition of the u.A. in the gastric mucosa occurring Cyclooxygenase 1 to be caused. The moreover disturbances can occur with the blood formation and hypersensitivity reactions.

Reciprocal effects

One the most important reciprocal effect finds with blood clotting-restraining substances such as z.B. Phenprocoumon instead of, their effect by Diclofenac is strengthened. Thus it can come to an increase of the bleeding danger.

It gives further reciprocal effects Lithium, Phenytoin and Herzglykosiden, their effect by Diclofenac is strengthened. Since it acts with these around substances with small therapy width, it can come to overdosing.

As therapeutic agent for the treatment of chord inflammations (tennis arm) it can come to allergischen reactions by turning red the skin under pain formation.

Contraindications

Because of the danger from over reactions Diclofenac is with patients also Asthma contraindicated. In addition Diclofenac should not be taken before larger operational interferences, since it the bleeding danger increases here.

Also with an available pregnancy Diclofenac may not be used.

For the use of Diclofenac with children and young people there are no sufficient studies, therefore application is not recommended.

Diclofenac becomes also as PAIN GEL (with pain, Fever, Inflammations and rheumatism) in Germany u.A. under the label name volt arene^® / Diclac^® used.

Application Dogs and Cats can substantial stomach intestine damages with partial lethal Exit cause and is strictly contraindicated therefore. The illness caused by administration of this medicine is one the most frequent (human -)iatrogenen Emergencies with dogs.

Contraindications

After newest scientific research and reports one could determine at pro gangs clearly, that the cardiac infarct risk rose around 24%, if patients before medicines with the active substance "Ibuprofen"had taken. Clearly more highly, indeed with 55% of all cases the risk of a life-threatening cardiac infarct rose with previous income of the active substance Diclofenac.

In the so far largest investigation of their kind those had examined professor inside Julia Hippisley Cox and Carol coup country of the University of Nottingham using up so-called nichtsteroidaler Entzuendungshemmer (NSAID) with 9218 cardiac infarct patients.To the NSAID belong among other things the widespread active substances Ibuprofen, Diclofenac and the Coxibe already come into the discussion.

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