Folsäure

Structural formula

general
name	Folsäure
trivial name	Vitamin B₉
other names	Pteroyl mono glutaminsäure, foil acid, n (4 (((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl) methyl) -< /br> amino) benzoyl) glow amine acid
sum formula	C₁₉ H₁₉ N₇ O₆
E-number	-
CAS number	59-30-3
short description	orange-yellow, crystalline powder
characteristics
mol mass	441.41 g mol
state of aggregation	firmly
density	- g/cm ³
melting point	-
boiling point	-
Solubility	water-solubly
dosage
daily need	400 µg
overdose	15 mg D
essential
occurrence	cattle liver, beans, yeast
as far as possible and common, SI-UNITs are used. If not differently notes, the indicated data apply with standard conditions.

The Folsäure, also foil acid or Pteroylglutaminsäure mentioned, is in1941 discovered, heat and photo-sensitive, water-soluble Vitamin from the B-complex. It is like Riboflavin, Vitamin B₆, a Pteridin - derivative.

1 occurrence
2 Vitaminverluste
3 Folsäure lack and false formations
4 discussion around Folsäure supply
5 Vitamin B-group
of 6 Folsäure products
7 Web on the left of

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Occurrence

Folsäure is contained in liver, full grain products, green sheet vegetable such as z. B. Spinach, Brokkoli, asparagus, tomatoes, Eigelb and Nüssen. Also in fruit, fish and meat are small quantities of it.

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Vitaminverluste

there the Vitaminlight, oxygen and heat sensitive as well as well water soluble, should to intensive landing on water is and to long camp and Kochzeiten be avoided.

To the human skin appropriate intensive solar radiation (UV-RADIATION) reduces the Folsäure in the body. With lightmembranous humans the effect is particularly strong.

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Folsäure lackand false formations

an absence of the Folsäure in the body Anencephalie of the new ral pipe particularly affects with can lead the embryo and to a Frühgeburt the blood picture and in the pregnancy to false formations such as Spina bifida or.

Also on illnesses of the cardiovascular system, like for example that Arteriosklerose, is important a sufficient supply of Folsäure. The value for the amino acid Homocystein in the blood is considered as cardiovascular factor of risk. Homocystein is converted with the help of the Folsäure into Methionin; the positive effects of increased Folsäuregaben, those and. A. a dropping of the Homocystein mirror cause, on thoseProgression of cardiovascular diseases are not undisputed however.

The recommended daily dose (after “reference values for the nutrient supply”, 1. Edition 2001 of the German society for nutrition registered association) amounts to 400 μg, for pregnant woman 600 μg and for satisfying mothers 600 μg. Folsäure should however only after detailed medical consultationare taken.

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discussion around Folsäure supply

of child physicians demand to mix to the basic food flour Folsäure in order to reduce the probability of false formations with children. On the other hand however Verbraucherschützer protest.

In the USA, in Canada and also in Hungary a Folsäurezusatz is legal in flourprescribed. Since nearly all humans take daily bread, cookies and other mehlhaltige products to itself, in these countries the supply of this Vitamin improved enormously. Measurable at the number of the children, who come with a new ral tubing defect to the world, as for example one is Form of Spina bifida, a Anenzephalie or a Kiefer palate column. Since one the flour mandatorily Folsäure added, is born in these countries only about half so many children with such false formations.

Child and newborn child physicians in Germany therefore demand that an also in this country Folsäurezusatzin the flour obligation will must, since a majority of the population, men and women is supplied with Folsäure equally, not sufficiently. Particularly for young women this represents a large problem, because a sufficient Folsäureversorgung above all completely plays an important role at the beginning of a pregnancy;during the new ral tubing formation the first three weeks are crucial. Go to approximately 50 per cent of the pregnant women women however only to being missing the Menstruation to the gynecologist - at one time, in which Folsäure tablets are ineffective for the prevention of false formations.

About 800 children come in the Federal Republic of Germanyannually with a new ral tubing defect to the world. Zirka each thousandth baby is not concerned, driven off children with Spina bifida is taken into account thereby. The consumer protection Ministry sees so far however no necessity for national initiatives, which lead to it, to mix to the flour Folsäure. Also nourishing experts of the consumer centers and. A. representedthe view, a mandatory enrichment of flour is not necessary, since it enough natural food, as fruit, vegetables and whole-meal bread give, which contained Folsäure. , Over the food the quantities of Folsäure, necessary for it, are to be left to the consumer to itself tootake. Food companies enrich besides already Müsliriegel, beverages, milk products and also salt with Folsäure and mark this accordingly.

Thus it is to be achieved that a conscious and healthy nutrition a goal of the consumers does not remain and the admission of Vitaminen such as Folsäure over unhealthy, artificially enriched foodin their place steps. Besides it is criticized that it gives too few long-term investigations to the risks of Folsäure.

It admits already is that too much Folsäure a Vitamin b₁₂ - lack to cover can. This comes however only with approx. 2 per cent of humans over 50 years before. ThatRobert institute for cook came to the result that “the admixture of Folsäure improves the Folatversorgung, without a over supply occurs with a substantial population portion”. Besides in this connection the additive of Vitamin B₁₂ is recommended.

In Germany the mandatory Folsäure Supplementierung in flour becomes from experts“interspersable” does not call, since the consumers of such an admixture would finally opposite-stand critically. Therefore in addition will turn out for young women to use common salt with Folsäure ( and iodine).

The German society for nutrition recommends one daily to admission of approx. 400 micro gram of Folsäure (women with child desire perikonzeptionell600 micro gram). But about two thirds of the adults women and men do not even come on 300 micro gram per day.

The “Folsäure offensive” - companies mark their products by “Biogerm telex”, if Folsäure from natural sources is used, and by “Biogerm FS+”, if additionally synthetically manufactured Folsäure is added.

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Vitamin B-group

concerns here it a collective term of water-soluble Vitamine, different, chemical compositions. Except the actual B-Vitaminen, like B₁ Thiamin, B₂ Riboflavin, B₆ Pyridoxin and B₁₂ Cobalamin one counts still Biotin, Folsäure, nicotine acid and Pantothensäure in addition. The group of the B-Vitamine occurs in animal and vegetable food. Without the factors (Coenzyme) of the B-group nearly no biochemical processes in the body run off. Vitamine of the B-group do not represent a uniform class. They are chemically and pharmakologisch completely different substances.Usually several B-Vitamine are involved in a physiological effect; therefore they do not come in nature isolated forwards.