As Hypervitaminose those features are summarized, which is with excessive supply of the appropriate Vitamine, it over the nutrition, in the form of food auxiliary means or Vitaminpräparaten, in addition, with parenteral gift, to arise to be able.
Particularly with the Vitaminen A and D can come it to overdosing features,also due to the fat-solubleness of these substances problems cause.
A Vitamin lack is marked with Hypovitaminose and an absence of Vitaminen with Avitaminose.
Table of contents
acute symptoms of intoxication
of acutes symptoms of intoxication were determined for the first time with polar explorers, who had eaten polar bear liver - Eskimos do not eat these. In the case of a brief and high overdosing (hundredfold of theDaily requirement and more) can occur the following symptoms:
- loss of appetite
- muscle co-ordination disturbances
- of double pictures
- Hautschäden (at the Mundwinkeln Hautabschilferungen beginning, which can spread on the entire body)
- mucous membrane bleedings
- increased intrakranieller pressure up to deaths.
chronic symptoms of intoxication
after month andincreased Retinolaufnahme for many years, those tenfold of the daily requirement exceeds - with which 50,000 IU or 15 mg per day, with children 20,000 IU or 6 mg per day - are possible the following symptoms:
- hair loss up to the Alopezie
- swelling the hypodermis of the member masses
- bone andJoint pain
- dry and itching scalp like also the entire remaining skin
- dry and flaky lips
- (bleeding) Mundwinkelrhagaden
- liver enlargement up to the Leberfibrose with portaler Hypertension
- lymph node enlargements
- being missing the Menstruation
- increased intrakranieller pressure
- probably on a long-term basis higher cancer of the lungs - risk with smokers
in the pregnancy should the daily admission of Vitamin A 10,000 IU and/or 3mg per day do not cross, since it can to be come otherwise to childlike false formations as kraniofacialen abnormalities or heart flap errors, however also spontaneous abortion are possible.
The Vitamin A Säureabkömmling Isoretinoin (13-cis-Retinsäure), which for treatment heavy acne forms is used, can a dryness of skin and mucous membranes, in rare cases joint and muscle complaints cause. V.a. but a connection with childlike false formations was manufactured, so that with a such treatment for a sufficient receipt sneezing protection also for a certain time beyond the treatment end must be ensured. With pregnant womenWomen is contraindicated the gift.
A Hypervitaminose A can only with supply of Retinol, not however its forerunner products arises - the transformation of the Carotinoide to Retinol is adjusted adapted to the need of the body. Probably however it can to a strong Gelbfäbung of the skin - notbut the Skleren - comes, if daily more than 30 mg beta Karotinen are supplied, whereby patients with a thyroid subfunction are particularly susceptible.
Carotin (Provitamin A) as chemical preliminary stage of Vitamin A is in brown caps contained, which can cause hair loss with excessive consumption allegedly.
Retinol is particularly in the liver of certain sea fish contained like the Heilbutt and different shark fish types as well as certain mammals like the sea-seal and the polar bear. In our widths it is v. A. the uncritical income of Vitaminpräparaten, which can lead to side effects.
could lead studies a too high supply of Vitamin A in the new England journal OF Medicine to increased fractures at the age, like a Swedish long-term study, (NEJM 2003; 348: 287? 294 one published), shows.
Vitamin B 3
with a supply of >500mg/day comes it to the strike-container-extending effect Flush and with a quantity of >2500 mg/day can the blood pressure sink, can feelings of dizziness occur and a increased urine acidity in the blood occur.
Taken over from article “Niacin”.
although again and again times of overdosing thoseSpeech is, meets one in the technical literature rarely in concrete cases, and if, then it becomes if necessary clearly that it concerns exotic cases. Thus with Vitamin B6 in the literature overdosing reactions are only described starting from 1.000 mg daily. A condition is the income over monthsaway. Foam castle et al. (1983) toxic reactions described, after patients took 2.000-6.000 mg over 2-40 months. Sensitive persons are to have already felt starting from 500 mg daily side effects. Generally it applies that dosages between 2 and 10 g can lead daily to neurological disturbances.
in high doses of 5-10 g daily (orally taken) can Vitamin C in individual cases to nausea, failure or loose chair course lead. Humans with an inclination to the formation of kidney stones should ask such high dosages before the income their physician.
the admission from more than 25 to 50 micro gram Vitamin D per day can lead to a calcium release from the bone and heartbeat disturbances. In principle 10 micro gram (400 I.E.) Vitamin D3 applies on the day as safe upper limit to the income.
an overdosing is possible only with intravenous gift.
on the left of CARET study 
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