Noradrenalin
Noradrenalin (also Norepinephrin) is on the one hand a neurotransmitter of the sympathetic nervous system and on the other hand a hormone of the Nebennierenmarkes. It predominantly works at the Arterien (arteries) of the large cycle and leads across activation of Adrenozeptoren to oneConstriction of these containers to a blood pressure increase. Noradrenalin is paid in the peripheral nervous system by Symphati nerve fibers.
Noradrenalin is closely related to the adrenalin (Nor = contains a group of methyls less) and belongs like this to the Katecholaminen. It is thoseCarrier substance (neurotransmitter) of the post office ganglion eras synapses of the sympathetic nervous system. The elimination of the Noradrenalins from the synaptic gap takes place mainly via Reuptake, i.e. Resumption of the Noradrenalins. So-called Noradrenalin Reuptakehemmer, like e.g. the cocaine lead to oneIncrease of the Noradrenalin concentration and thus for an increase of the sympatheticotonus.
In the Locus coeruleus, a relatively small, dark-colored cell's group in the central brain, a majority of the Noradrenalins of the ZNS is produced. Benzodiazepine decrease the activity of the Locus coeruleus and reducethus the transport from Noradrenalin to the front brain.
Increased mirrors of the Noradrenalins in the blood are with the heart insufficiency and with the Phäochromozytom.
therapeutic employment
the hormone comes under the company name Arterenol also as medicine in that Intensive medicine to the employment. It carries thereby good services out with the treatment of the following diseases:
- septischer shock
- anaphylaktischer shock
- poisonings with Vasodilatation
it is intravenously mostly given thereby by means of syringe pump. Noradrenalin should be proportioned as low as possible, there it thatHeart the Pumparbeit makes more difficult. Principal purpose parameter of the dosage is a sufficient kidney elimination. Usually Noradrenalin with a relatively high liquid gift is combined, in order to fill up the intravasale volume.
The medicine becomes local the prevention of bleedings with operation usually together with a restaurant anaestheticeingesesetzt.
As alternative one can use adrenalin, in particular then although the heart frequency is low.
contraindications
Noradrenalin may not be used or only very carefully with the following conditions:
- Blood high pressure (hypertonia)
- of heavy thyroid hyperactivity (Hyperthyreose)
- Phäochromozytom
- Engwinkelglaukom
- You consider enlargement of the Prostata
- with remainder urine formation
- accumulation-wise
- heart chase Tachyarrhythmie
- of heavy kidney insufficiency of heavy Koronarsklerose or
- heavy heart muscle insufficiency of heavy Arteriosklerose
- with Stenosen
work on
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