Tetracycline

Those Tetracycline (or in more eingedeutschter Posting Tetrazykline) are antibiotic effective medicine materials ( Protein synthesis at of them and restrain thus their growth (bakteriostatische Effectiveness) of grampositiven, gramnegativen and numerous cell wallless .

Chemistry

Tetracycline are tetrazyklische biogenous medicine materials, from Streptomyces kinds over that Polyketid way are synthesized.

Streptomyces aureofaciens could already in the year 1948 as a producer of Chlortetracyclin are identified. If this bacterium in a chloride-poor medium is bred, then it produces the therapeutically used . For the production of Tetracyclinen is suitable beyond that Streptomyces rimosus (Oxytetracyclin).

Further Tetracycline, like z.B. Doxycyclin and Minocyclin partialsynthetische derivatives, those from other Tetracyclinen, are like z.B. Oxytetracyclin, to be manufactured. They differ from other Tetrazyklinen in particular in their pharmakokinetischen characteristics, like z.B. the enrichment in and in that Skin. Rolitetracyclin is a water-soluble Prodrug the Tetracyclins with a modified amide group in position 2.

Pharmacology

Effect mechanism

Like also Macro eyelid, Lincosamide, and the Tetracycline restrains those protein biosynthesis. The Tetracycline prevents the accumulation of the Aminoacyl to the acceptor places of the 30S-Untereinheit of the Ribosomen and thus the extension of the Peptidkette. Their comparatively small toxicity for humans can by their selective interaction with bacterial Ribosomen, not however also eukaryontischen Ribosomen to be explained.

Effect spectrum

Tetracycline affect bakteriostatisch grampositive (z.B. and , Camphylobacter and Neisserien). Its Wirkungsamkeit is of special importance with the fight of cell wallless problem germs (z.B. Mykoplasmen, and and Treponemen). Some Tetrazykline possess beyond that a clinical effectiveness approximately (, ).

Resistances

Unfortunately it particularly gives in already many resistances. Numerous in particular and the Tetracycline are in particular on their strong Calciumto lead back binding characteristics. Tetracycline should not therefore , or in the growth phase to be used, because it into those and into those to be inserted, which to a yellow colouring of the teeth, a increased and to increased fractures leads.

By their broad spectrum they also the natural dezimieren Kolonisationsflora relatively strongly and supply rarely Pseudomembranous Colitis.

Furthermore they can to a photosensitization that Skin and like many different to nonspecific Belly and (here: Swindle) lead. As the further side effect skin excursion and itching can appear, those approx.. 2 days after setting the medicine off disappear. A hepatotoxische effect, which is to be observed after gift of high Tetracyclindosen, can possibly on an interaction of the Tetracycline with the bacteriasimilar Ribosomen that Mitochondrien are led back.

Pharmakokinetik

Doxycyclin and Minocyclin are taken up in the intestine normally too over 90% (Tetracyclin: 80%) and particularly over those of 15 (Tetracyclin: 9h) separated.

The dose range is with Doxycyclin with 0,1 to 0,2 per .

Reciprocal effects

Tetracycline can by multi-valued metal ions (z.B. Approx.²⁺, mg²⁺ and Fe³⁺) to be bound. Tetracycline should not therefore together with CalciumCarriers (. Also , and (Antazida) form Complex connections with the Tetracyclinen. The effectiveness that Contraceptive pill is not ensured.

Please you consider also that !