Wernicke Enzephalopathie

the Wernicke Enzephalopathie (syn.: Polioencephalopathia haemorrhagica superior; English: Wernicke's encephalopathy; designated after Carl who-nod 1848 - 1905) are a degenerative illness of the brain in the adult age. It arises particularly with Vitaminmangel (mark absorption syndrome).

concerning

a Wernicke Enzephalopathie is with approximately 15% of the deceased alcoholics. Rarer causes are a stomach karzinom, stomach resektion or a long persisting parenteral nutrition without addition of Vitamin a B1 (Thiamin).

Emergence

to reason lies a Vitamin B1-Mangel (Thiamin), which leads to disturbances in the coal hydrate metabolism by failure of a phosphorylation high-energy. To an edematous swelling of the brain it comes later also to the a bleeding and Kapillarsprossung in certain places of the brain (corpora mamillaria, hypothalamische central areasaround III. Ventricle, Lamina tecti and periaquäduktales grey with Okulomotoriuskerngebieten). A Atrophie follows these structures.

symptoms

disturbances when moving the eyes by eye muscle paralyses and doubling seeing, horizontal Blickrichtungsnystagmus, reflex disturbances, consciousness disturbances, disorientationness, apathy and Somnolenz, cerium Bell acres trunk, standing and courseAtaxia, disturbances of the Feinmotorik with Dysdiadochokinese, bulbär cerebelläre speech disturbance (Dysarthrie), sip disturbance (Dysphagie), sleep disturbance (Imsomnie), vegetative disturbances such as Hypotonie, hypothermia and Hyperhidrose, organic Psychose.

therapy

Vitamin substitution by intravenous gift of Thiamin. Untreatedly the illness can run deadly.

see also

Wernicke Aphasie, Wernicke Korsakow syndrome, Enzephalopathie, Beriberi

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