Disease of Whipple

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disease of Whipple is one rare disease had with bacterium Tropheryma whipplei. The spontaneous evolution of the disease is long, marked by episodes of remission and of relapses being able to evolve/move until death in antibiotic absence of treatment.

Its first description is due to George Hoyt Whipple in 1907 ("Whipple GH. With hitherto undescribed disease characterized anatomically by deposits of conceited and fatty acid in the intestinal and mesenteric lymphatic tissues. Bull Johns Hopkins Hosp 1907;18:382-93.")

Signs and symptoms

• Traditional demonstrations
  • Articular pains
  • syndrôme of malabsorption
  • Abdominal pains
  • Cutaneous pigmentation
• Fever
• Attack of central nervous system
  • Insanity
  • Abnormal movements of the ocular spheres
• Attacks cardiovascular
  • Péricardite
• etc.

Diagnosis

Complementary examinations

• Proportioning of greases in the saddles to confirm stéatorrhée.
• With the baryté transit one notes one hypertrophy villositaire

Aspect of the biopsies

Etiology

The causes can be genetics and of the blow the disease can be declared after a psychological shock, a stress... It probably has an infectious component, associated a dysfunction of origin car-immune.

Treatment

This disease requires one antibiothérapie with the long course. One associates it in the forms engraves one corticothérapie.

Epidemiology

It acts of a relatively rare disease, few things are thus known on this disease, except that it preferentially touches the men of more than 50 years.

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