Aceto amino foehn
Chemical compoundAceto amino foehn(Alias パラセタモール), it is one of the solution thermal anesthetic medicine. It has become with one of the principal component of the medicine which is used light heat generation and, coldly as the antifebrile and the pain reliever which hold down condition such as け and headache. Generally the antifebrile even the case of the influenza which makes taboo as an antifebrile with standard taking method is the very safe medicine e.g., often it is used, but because of the wide medicinal effect, it is not few for the taking quantity to become excessive.
Furthermore, aceto amino foehn does not have anti- inflammation action the non steroid characteristic anti- inflammation medicine of aspirin and eve professional foehn etc. (NSAID) unlike. In addition, at the normal taking quantity, as for aceto amino foehn it does not stimulate the stomach unlike the non steroid characteristic anti- inflammation medicine, there is no influence such as blood clotting and arteriosclerosis of the kidney or the fetus. In addition, the オピオイド pain reliever (the morphine and the like) unlike, there is no problem regarding poisoning, the dependency, resistance and withdrawal phenomenon completely you say it has advantage that excitation, there is no side effect of the sleeping け and the multi happiness symptoms etc.. Furthermore, it is pulled up aspirin and eve professional foehn, by NSAID such as ナプロキセン and ジクロフェナク the patient of the "aspirin asthma" being, there is also the report that with aceto amino foehn it is difficult to cause the asthma.
Molecular formulaC8H9NO2.
History
As for aceto amino foehn1873It was synthesized for the first time. As for being used as the medical supply1893So it is.
Action mechanism
By the fact that シクロオキシゲナーゼ (COX) activity is obstructedProfessional star Glan ginProduction is controlled, solution thermal anesthetic action is brought.AspirinThe effect is weak and so on with by comparison.
Side effect
It exists inside the human bodyシトクロム P450Aceto amino foehn is oxidized,Acetamide quinoneIt forms. Acetamide quinone is the strong electrophilic reagent,Glutathione(GSH)Thiol basisAnd inside cellProteinWith it reacts. Therefore when aceto amino foehn is taken in abundantly, liver virulence appears. However, if remedy level this does not become problem.
- Liver obstacle
- Simultaneous intake from the alcohol to be easy to cause liver obstacle is dangerous.
- Blood platelet, leucocyte decrease
- Evil intention and vomiting
And so on
