Pepsin

Pepsin (EC.3.4.23.1-3) Animal stomach proteolytic enzyme. One of aspartic acid protease.

Table of contents

Character

GeneTranslationThe product inactive type is the precusorThe Pepsi-Cola no geneIt is made with mucous membrane of the stomach as. This hydrochloric acidpH, becomes the pepsin of active type by cutting down the professional arrangement of N terminal side with processing of two stages. Strongly it is aciditypH2.Vicinity of 0 is optimum condition. One time when it makes neuter alkaline condition, three-dimensional structure denaturalizes the pepsin which is activated irreversibly and loses activity.

Substrate peculiarity

The acidic amino acid residue of the protein peptide chain - C terminal side of the arrangement which continues with the aromatic amino acid residue is cut off.

Inhibitor

It is obstructed by pepstatin A and the like.

Related item

  • digestion
  • digestion enzyme
  • protease

 

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