Tetracycline
Tetracycline an antimicrobic substance is (antibiotic) that by bacterium line Streptomyces is produced. It is geïndiceerd at a large scale to bacterial infecties, both gramme-positive as gramme-negative, and vele other micro-organismen among which spirocheten, actinomyceten and a number of protozoën. Moulds and viruses are insensitive for the medecine. Tetracycline belong to the group antibiotics which tetracyclinen or also kortweg cyclinen is called, all inferred forms of the head component tetracycline. It is sold in the world under many several names, among which Tetralysal 300®, Panmycin®, Brodspec® and Tetracap®. The substance was for the first time discovered Lloyd Conover in the research centres of medicine manufacturer Pfyzer and the patent was obtained 1955.
functioning mechanism
Tetracycline inhibeert cell increase by the inhiberen of translatie. It binds to 30S ribosomale subunit and prevent that amino-acyl bind tRNA to a spot of ribosome. This tie is reversibel in nature. Bacteria are possible rather rapidly resistent become against tetracycline. Resistentie can be the consequence of at least two mechanisms. First resistentiegen can produce membraaneiwit that tetracycline the cell from pump actively. This is the functioning mechanism of the tetracyclineresistentiegen on the artificial plasmide pBR322. A second mechanism means of which can protect himself a bacterium against tetracycline is ribosomale protection, where resistentiegen encode an endosperm that binds to ribosome and this way prevents that tetracycline bind to this.
Counter-indications
From research has become clear that tetracycline can be detrimental during pregnancy, because it the botopbouw slowed down and the cog development unfavourably influenced. Since it proceeds also in mother milk use during giving udder feeding is advised against. Also at children younger than 8 years of age the means is not administered preferably. Verder dient tetracycline niet langer dan de uiterste houdbaarheidsdatum te worden gebruikt. After this date the means can become toxic and serious kidney damage to cause.
